“In the United States, we have some of the world's most advanced medical technology, highly specialized care, and world-class emergency services. At the same time, the system is inefficient, inequitable, and unsatisfying to nearly everyone who interacts with it. My friend Marschall Runge offers a compelling prescription for disruption. With four decades of experience—much of it at the very top of academic medicine—his insights are not only well-informed but well worth our attention.” — Sanjay Gupta, MD Associate Chief of Neurosurgery, Grady Memorial Hospital; Associate Professor of Neurosurgery, Emory University School of Medicine; Chief Medical Correspondent, CNN; bestselling author and host of Chasing Life podcast

“Dr. Marschall Runge delivers a bold and visionary roadmap for transforming American healthcare. With clarity and conviction, he explores how emerging technologies can revolutionize care—making it more affordable, equitable, and effective for all. But this is more than a call for innovation—it is a call for accountability. Dr. Runge challenges us to ask who truly benefits from progress, who is being left behind, and what courageous leadership must look like in this era of unprecedented disruption. This is a vital and timely contribution to the urgent conversation about the future of medicine—and what it must become to serve society in the 21st century.” — Victor J. Dzau, MD President, National Academy of Medicine; Chancellor Emeritus, Duke University Health System

“In a pivotal era marked by entrepreneurship, innovation, and significant change in healthcare, Dr. Marschall Runge, a physician and healthcare leader, stands out as a seasoned voice in American medicine, speaking with both candor and courage. The Great Healthcare Disruption serves as a masterclass in leadership, exposing the systemic failures of our healthcare system, while presenting pragmatic solutions for reinvention. This book is not merely an academic text; it's a comprehensive blueprint for the bold transformation our nation urgently needs.” — Michael M.E. Johns, MD Executive Vice President for Health Affairs Emeritus, Emory University; Founding CEO Emory Healthcare; Former Dean, Johns Hopkins School of Medicine